Progress in Electrochemical MIP Sensors for Detection of Bisphenol A: A Mini review
DOI:
https://doi.org/10.51574/hayyan.v3i2.5151Keywords:
Bisphenol A, molecularly imprinted polymer, electrochemical sensor, Voltammetric sensorsAbstract
Bisphenol A (BPA) is an endocrine-disrupting chemical widely used in the production of polycarbonate plastics and epoxy resins, raising concerns regarding its migration into food, beverages, and the environment. This mini-review summarizes recent advances in molecularly imprinted polymer (MIP)-based electrochemical sensors for BPA detection, with emphasis on recent developments in sensor fabrication, nanomaterial modification, and analytical performance. The review discusses MIP synthesis strategies, sensor platforms, nanomaterial modifications, and analytical performance. Recent studies have demonstrated that MIP-based electrochemical sensors can achieve highly sensitive BPA detection with limits of detection ranging from 0.03 pM to 52 nM, wide linear ranges, and successful application in real samples such as drinking water, milk, and packaged beverages. The incorporation of nanomaterials, including graphene, carbon nanotubes, and gold nanoparticles, has significantly improved electron transfer, sensitivity, and selectivity. Despite these advances, challenges related to long-term stability, reproducibility, template removal efficiency, and matrix interference remain. Overall, MIP-based electrochemical sensors represent a promising platform for rapid, selective, and cost-effective BPA monitoring in environmental and food safety applications.
References
Anirudhan, T. S., Athira, V. S., & Chithra Sekhar, V. (2018). Electrochemical sensing and nano molar level detection of Bisphenol-A with molecularly imprinted polymer tailored on multiwalled carbon nanotubes. Polymer, 146, 312–320. https://doi.org/10.1016/j.polymer.2018.05.052
Ben Messaoud, N., Ait Lahcen, A., Dridi, C., & Amine, A. (2018). Ultrasound assisted magnetic imprinted polymer combined sensor based on carbon black and gold nanoparticles for selective and sensitive electrochemical detection of Bisphenol A. Sensors and Actuators B: Chemical, 276, 304–312. https://doi.org/10.1016/j.snb.2018.08.092
Bodur, S., Erarpat, S., Dalgıç Bozyiğit, G., Selali Chormey, D., Öz, E., Özdoğan, N., & Bakırdere, S. (2020). A sensitive determination method for trace bisphenol A in bottled water and wastewater samples: Binary solvent liquid phase microextraction-quadrupole isotope dilution-gas chromatography-mass spectrometry. Microchemical Journal, 159, 105532. https://doi.org/10.1016/j.microc.2020.105532
Cimmino, I., Fiory, F., Perruolo, G., Miele, C., Beguinot, F., Formisano, P., & Oriente, F. (2020). Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease. International Journal of Molecular Sciences, 21(16), 5761. https://doi.org/10.3390/ijms21165761
Czarny-Krzymińska, K., Krawczyk, B., & Szczukocki, D. (2023). Bisphenol A and its substitutes in the aquatic environment: Occurrence and toxicity assessment. Chemosphere, 315, 137763. https://doi.org/10.1016/j.chemosphere.2023.137763
Dykstra, G., Reynolds, B., Smith, R., Zhou, K., & Liu, Y. (2022). Electropolymerized Molecularly Imprinted Polymer Synthesis Guided by an Integrated Data-Driven Framework for Cortisol Detection. ACS Applied Materials & Interfaces, 14(22), 25972–25983. https://doi.org/10.1021/acsami.2c02474
Ekomo, V. M., Branger, C., Bikanga, R., Florea, A.-M., Istamboulie, G., Calas-Blanchard, C., Noguer, T., Sarbu, A., & Brisset, H. (2018). Detection of Bisphenol A in aqueous medium by screen printed carbon electrodes incorporating electrochemical molecularly imprinted polymers. Biosensors and Bioelectronics, 112, 156–161. https://doi.org/10.1016/j.bios.2018.04.022
Hamed, E. M., & Li, S. F. Y. (2022). Molecularly imprinted polymers-based sensors for bisphenol-A: Recent developments and applications in environmental, food and biomedical analysis. Trends in Environmental Analytical Chemistry, 35, e00167. https://doi.org/10.1016/j.teac.2022.e00167
Han, E., Pan, Y., Li, L., & Cai, J. (2023). Bisphenol A detection based on nano gold-doped molecular imprinting electrochemical sensor with enhanced sensitivity. Food Chemistry, 426, 136608. https://doi.org/10.1016/j.foodchem.2023.136608
Hu, X., Feng, Y., Wang, H., Zhao, F., & Zeng, B. (2018). A novel bisphenol A electrochemical sensor based on a molecularly imprinted polymer/carbon nanotubes-Au nanoparticles/boron-doped ordered mesoporous carbon composite. Analytical Methods, 10(37), 4543–4548. https://doi.org/10.1039/C8AY01611A
Kadhem, A. J., Gentile, G. J., & Fidalgo de Cortalezzi, M. M. (2021). Molecularly Imprinted Polymers (MIPs) in Sensors for Environmental and Biomedical Applications: A Review. Molecules, 26(20), 6233. https://doi.org/10.3390/molecules26206233
Karthika, P., Shanmuganathan, S., Viswanathan, S., & Delerue-Matos, C. (2021). Molecularly imprinted polymer-based electrochemical sensor for the determination of endocrine disruptor bisphenol-A in bovine milk. Food Chemistry, 363, 130287. https://doi.org/10.1016/j.foodchem.2021.130287
Li, Y., Luo, L., Kong, Y., Li, Y., Wang, Q., Wang, M., Li, Y., Davenport, A., & Li, B. (2024). Recent advances in molecularly imprinted polymer-based electrochemical sensors. Biosensors and Bioelectronics, 249, 116018. https://doi.org/10.1016/j.bios.2024.116018
Liu, B., Yan, J., Wang, M., & Wu, X. (2019). Molecularly imprinted electrochemical sensor for the detection of bisphenol A. International Journal of Electrochemical Science, 14(4), 3610–3617. https://doi.org/10.20964/2019.04.58
Metwally, M. G., Shehab, O. R., Ibrahim, H., & El Nashar, R. M. (2022). Electrochemical detection of Bisphenol A in plastic bottled drinking waters and soft drinks based on molecularly imprinted polymer. Journal of Environmental Chemical Engineering, 10(3), 107699. https://doi.org/10.1016/j.jece.2022.107699
Niu, X., Yang, W., Wang, G., Ren, J., Guo, H., & Gao, J. (2013). A novel electrochemical sensor of bisphenol A based on stacked graphene nanofibers/gold nanoparticles composite modified glassy carbon electrode. Electrochimica Acta, 98, 167–175. https://doi.org/10.1016/j.electacta.2013.03.064
Nugroho, B., Pramudya, Y., & Widodo, W. (2019). The Content Analysis of Bisphenol A (BPA) on Water in Plastic Glass with Varying Temperatures and Contact Times using UV-VIS Spectrophotometer. Indonesian Review of Physics, 1(2), 27. https://doi.org/10.12928/irip.v1i2.263
Önal Acet, B., İnanan, T., Salieva, K., Borkoev, B., Odabaşı, M., & Acet, Ö. (2024). Molecular imprinted polymers: important advances in biochemistry, biomedical and biotechnology. Polymer Bulletin, 81(12), 10439–10459. https://doi.org/10.1007/s00289-024-05238-5
Pop, C.-E., Miu, B. A., Németh, D., Wolff, R., Mihăilescu, D. F., Avramescu, S. M., & Mernea, M. (2024). Bisphenol A analysis and quantification inconsistencies via HPLC-UV: a systematic review with technical notes. Discover Applied Sciences, 6(4), 171. https://doi.org/10.1007/s42452-023-05617-z
Saylan, Y., Akgönüllü, S., Yavuz, H., Ünal, S., & Denizli, A. (2019). Molecularly Imprinted Polymer Based Sensors for Medical Applications. Sensors, 19(6), 1279. https://doi.org/10.3390/s19061279
Stevens, S., Bartosova, Z., Völker, J., & Wagner, M. (2024). Migration of endocrine and metabolism disrupting chemicals from plastic food packaging. Environment International, 189, 108791. https://doi.org/10.1016/j.envint.2024.108791
Szubartowski, S., & Tuzimski, T. (2023). A Fast Method for Determination of Seven Bisphenols in Human Breast Milk Samples with the Use of HPLC-FLD. Molecules, 28(3), 1432. https://doi.org/10.3390/molecules28031432
Vilarinho, F., Sendón, R., van der Kellen, A., Vaz, M. F., & Silva, A. S. (2019). Bisphenol A in food as a result of its migration from food packaging. Trends in Food Science & Technology, 91, 33–65. https://doi.org/10.1016/j.tifs.2019.06.012
vom Saal, F. S., Nagel, S. C., Coe, B. L., Angle, B. M., & Taylor, J. A. (2012). The estrogenic endocrine disrupting chemical bisphenol A (BPA) and obesity. Molecular and Cellular Endocrinology, 354(1–2), 74–84. https://doi.org/10.1016/j.mce.2012.01.001
Xu, R., Qian, X., Zhang, Z., Yuan, F., Song, Y., Liu, J., Zhang, Q., & Wei, J. (2022). A molecularly Imprinted Electrochemical Sensor Based on N-MWCNT/CPE for Highly Sensitive and Selective Detection of Bisphenol A. International Journal of Electrochemical Science, 17(5), 220536. https://doi.org/10.20964/2022.05.06
Zhang, Y., Zhang, W., Zhang, L., Song, G., Wang, N., Xu, W., & Huang, W. (2021). A molecularly imprinted electrochemical BPA sensor based on multi-walled carbon nanotubes modified by CdTe quantum dots for the detection of bisphenol A. Microchemical Journal, 170, 106737. https://doi.org/10.1016/j.microc.2021.106737
Downloads
Published
Versions
- 2026-06-09 (3)
- 2026-06-09 (2)
- 2026-06-05 (1)
