Literature Review: Network Pharmacology as a New Approach and Trend in Medicine
DOI:
https://doi.org/10.51574/hayyan.v1i1.1130Keywords:
Network Pharmacology, Therapeutics, ComputationAbstract
Network pharmacology is a new approach to medicine that aims to understand drug interactions with body tissues more specifically. This concept involves a deep understanding of the mechanisms of drug action, drug metabolism, and the influence of drugs on tissue function. In recent years, network pharmacology has become a significant trend in drug development. This approach allows researchers to design drugs that are more effective and have fewer side effects. By understanding in detail how drugs interact with specific tissues, specific and targeted drug development can be undertaken. Network pharmacology also opens the door to the development of more particular and existent therapies. By taking into account individual differences in response to drugs, this approach allows for more effective and safer treatment. This article presents a literature review of network pharmacology as a new approach and trend in medicine. This literature review also explores the latest research and current trends in the world of medicine using a network pharmacology approach.This article shows that tissue pharmacology has great potential in more effective and safer treatments. With a better understanding of drug - tissue interactions, we can develop more targeted therapies and reduce the risk of undesirable side effects.
References
Chandran U, Mehendale N, Patil S, Chaguturu R, Patwardhan B. Network Pharmacology. Innovative Approaches in Drug Discovery. 2017:127–64. doi: 10.1016/B978-0-12-801814-9.00005-2. Epub 2016 Oct 14. PMCID: PMC7148629.
Hopkins, A. Network pharmacology: the next paradigm in drug discovery. Nat Chem Biol 4, 682–690 (2008). https://doi.org/10.1038/nchembio.118
Hopkins, A. Network pharmacology. Nat Biotechnol 25, 1110–1111 (2007). https://doi.org/10.1038/nbt1007-1110
Pandita V, Parihar A, Parihar DS, Panda S, Shanmugarajan D, Kumari L, Badwaik HR. System and network biology-based computational approaches for drug repositioning. Computational Approaches for Novel Therapeutic and Diagnostic Designing to Mitigate SARS-CoV-2 Infection. 2022:267–90. doi: 10.1016/B978-0-323-91172-6.00003-0. Epub 2022 Jul 15. PMCID: PMC9300680.
Waldman SA, Terzic A. Advancing pharmacometrics and systems pharmacology. Clin Pharmacol Ther. 2012 Nov;92(5):535-7. doi: 10.1038/clpt.2012.151. PMID: 23085873; PMCID: PMC5540435.
Bateman DN, McInnes GT, Webb DJ. Clinical pharmacology and therapeutics in a changing world. Br J Clin Pharmacol. 1999 Jul;48(1):1-3. doi: 10.1046/j.1365-2125.1999.00988.x. PMID: 10383551; PMCID: PMC2014879.
Marius M. Hoeper, Pharmacological therapy for patients with chronic thromboembolic pulmonary hypertension.European Respiratory Society0905-9180,1600-0617, Received February 6, 2015 Accepted March 19, 2015, Published online May 31, 2015. https://doi.org/10.1183/16000617.00001015
Mendell JR, Al-Zaidy SA, Rodino-Klapac LR, Goodspeed K, Gray SJ, Kay CN, Boye SL, Boye SE, George LA, Salabarria S, Corti M, Byrne BJ, Tremblay JP. Current Clinical Applications of In Vivo Gene Therapy with AAVs. Mol Ther. 2021 Feb 3;29(2):464-488. doi: 10.1016/j.ymthe.2020.12.007. Epub 2020 Dec 10. PMID: 33309881; PMCID: PMC7854298.
Joules A, Connors J, Johnson R, Van Orsow EA, McKenna DH, Nikiforow S, Ritz J, Gee A, Hubel A. Comparative analysis of cell therapy infusion workflows at clinical sites. Cytotherapy. 2021 Apr;23(4):285-292. doi: 10.1016/j.jcyt.2020.12.008. Epub 2021 Jan 30. PMID: 33531267; PMCID: PMC9013238.
Furukawa Y, Hamano Y, Shirane S, Kinoshita S, Azusawa Y, Ando J, Nakauchi H, Ando M. Advances in Allogeneic Cancer Cell Therapy and Future Perspectives on "Off-the-Shelf" T Cell Therapy Using iPSC Technology and Gene Editing. Cells. 2022 Jan 13;11(2):269. doi: 10.3390/cells11020269. PMID: 35053386; PMCID: PMC8773622.
Zhang X, Zhu L, Zhang H, Chen S, Xiao Y. CAR-T Cell Therapy in Hematological Malignancies: Current Opportunities and Challenges. Front Immunol. 2022 Jun 10;13:927153. doi: 10.3389/fimmu.2022.927153. PMID: 35757715; PMCID: PMC9226391.
Satpathy M, Wang L, Zielinski RJ, Qian W, Wang YA, Mohs AM, Kairdolf BA, Ji X, Capala J, Lipowska M, Nie S, Mao H, Yang L. Targeted Drug Delivery and Image-Guided Therapy of Heterogeneous Ovarian Cancer Using HER2-Targeted Theranostic Nanoparticles. Theranostics. 2019 Jan 24;9(3):778-795. doi: 10.7150/thno.29964. PMID: 30809308; PMCID: PMC6376473.
Jiaran Zhang, Huichun Tian, Lili Mao, Lu Si, Treatment of acral and mucosal melanoma: Current and emerging targeted therapies, Critical Reviews in Oncology/Hematology,Volume 193, 2024,104221,ISSN 1040-8428, https://doi.org/10.1016/j.critrevonc.2023.104221. (https://www.sciencedirect.com/science/article/pii/S1040842823003098)
Sandeep Wadekar, Dileep Kumar Singh, A modified convolutional neural network framework for categorizing lung cell histopathological image based on residual network, Healthcare Analytics, Volume 4, 2023, 100224, ISSN 2772-4425, https://doi.org/10.1016/j.health.2023.100224. (https://www.sciencedirect.com/science/article/pii/S2772442523000916)
Abid Haleem, Mohd Javaid, Ravi Pratap Singh, Shanay Rab, Rajiv Suman, Applications of nanotechnology in medical field: a brief review, Global Health Journal, Volume 7, Issue 2, 2023,Pages 70-77,ISSN 2414-6447, https://doi.org/10.1016/j.glohj.2023.02.008. (https://www.sciencedirect.com/science/article/pii/S2414644723000337)
Malik S, Muhammad K, Waheed Y. Nanotechnology: A Revolution in Modern Industry. Molecules. 2023 Jan 9;28(2):661. doi: 10.3390/molecules28020661. PMID: 36677717; PMCID: PMC9865684.
Yan Hu, Peishan Hu, Xiaozhong Peng, TIM-3 blockade: immune and targeted therapy in DIPG, Trends in Molecular Medicine, 2023, ISSN 1471-4914, https://doi.org/10.1016/j.molmed.2023.11.014. (https://www.sciencedirect.com/science/article/pii/S1471491423002769)
Elizabeth Silver, Alessia Argiro, Kimberly Hong, Eric Adler, Gene therapy vector-related myocarditis, International Journal of Cardiology, 2023, 131617,ISSN 0167-5273, https://doi.org/10.1016/j.ijcard.2023.131617. (https://www.sciencedirect.com/science/article/pii/S0167527323017072)
Charlotte O’Brien Gore, Amy Billman, Suchete Hunjan, Jayne Colebrook, Desmond Choy, Wilson Li, Jack Haynes, Jennifer Wade, Emily Hobern, Louisa McDonald, Sophie Papa, Martijn Brugman, Shahram Kordasti, Claudia Montiel-Equihua, Pre-treatment with systemic agents for advanced NSCLC elicits changes in the phenotype of autologous T cell therapy products,Molecular Therapy - Oncolytics,Volume 31, 2023,100749, ISSN 2372-7705, https://doi.org/10.1016/j.omto.2023.100749. (https://www.sciencedirect.com/science/article/pii/S2372770523000980)
Li, L., Yang, L., Yang, L. dkk. Farmakologi jaringan: cahaya penuntun yang terang dalam cara mengeksplorasi pengobatan tepat yang dipersonalisasi dari pengobatan tradisional Tiongkok. Dagu Med 18 , 146 (2023). https://doi.org/10.1186/s13020-023-00853-2
Xue H., Li J., Xie H., Wang Y. Review of drug repositioning approaches and resources. International Journal of Biological Sciences. 2018;14(10):1232–1244. doi: 10.7150/ijbs.24612.
Barabási A.L., Gulbahce N., Loscalzo J. Network medicine: A network-based approach to human disease. Nature Reviews Genetics. 2011;12(1):56–68. doi: 10.1038/nrg2918.
Hopkins, A. Network pharmacology: the next paradigm in drug discovery. Nat Chem Biol 4, 682–690 (2008). https://doi.org/10.1038/nchembio.118
Hopkins, A. Network pharmacology. Nat Biotechnol 25, 1110–1111 (2007). https://doi.org/10.1038/nbt1007-1110
Pandita V, Parihar A, Parihar DS, Panda S, Shanmugarajan D, Kumari L, Badwaik HR. System and network biology-based computational approaches for drug repositioning. Computational Approaches for Novel Therapeutic and Diagnostic Designing to Mitigate SARS-CoV-2 Infection. 2022:267–90. doi: 10.1016/B978-0-323-91172-6.00003-0. Epub 2022 Jul 15. PMCID: PMC9300680.
Waldman SA, Terzic A. Advancing pharmacometrics and systems pharmacology. Clin Pharmacol Ther. 2012 Nov;92(5):535-7. doi: 10.1038/clpt.2012.151. PMID: 23085873; PMCID: PMC5540435.
Bateman DN, McInnes GT, Webb DJ. Clinical pharmacology and therapeutics in a changing world. Br J Clin Pharmacol. 1999 Jul;48(1):1-3. doi: 10.1046/j.1365-2125.1999.00988.x. PMID: 10383551; PMCID: PMC2014879.
Marius M. Hoeper, Pharmacological therapy for patients with chronic thromboembolic pulmonary hypertension.European Respiratory Society0905-9180,1600-0617, Received February 6, 2015 Accepted March 19, 2015, Published online May 31, 2015. https://doi.org/10.1183/16000617.00001015
Mendell JR, Al-Zaidy SA, Rodino-Klapac LR, Goodspeed K, Gray SJ, Kay CN, Boye SL, Boye SE, George LA, Salabarria S, Corti M, Byrne BJ, Tremblay JP. Current Clinical Applications of In Vivo Gene Therapy with AAVs. Mol Ther. 2021 Feb 3;29(2):464-488. doi: 10.1016/j.ymthe.2020.12.007. Epub 2020 Dec 10. PMID: 33309881; PMCID: PMC7854298.
Joules A, Connors J, Johnson R, Van Orsow EA, McKenna DH, Nikiforow S, Ritz J, Gee A, Hubel A. Comparative analysis of cell therapy infusion workflows at clinical sites. Cytotherapy. 2021 Apr;23(4):285-292. doi: 10.1016/j.jcyt.2020.12.008. Epub 2021 Jan 30. PMID: 33531267; PMCID: PMC9013238.
Furukawa Y, Hamano Y, Shirane S, Kinoshita S, Azusawa Y, Ando J, Nakauchi H, Ando M. Advances in Allogeneic Cancer Cell Therapy and Future Perspectives on "Off-the-Shelf" T Cell Therapy Using iPSC Technology and Gene Editing. Cells. 2022 Jan 13;11(2):269. doi: 10.3390/cells11020269. PMID: 35053386; PMCID: PMC8773622.
Zhang X, Zhu L, Zhang H, Chen S, Xiao Y. CAR-T Cell Therapy in Hematological Malignancies: Current Opportunities and Challenges. Front Immunol. 2022 Jun 10;13:927153. doi: 10.3389/fimmu.2022.927153. PMID: 35757715; PMCID: PMC9226391.
Satpathy M, Wang L, Zielinski RJ, Qian W, Wang YA, Mohs AM, Kairdolf BA, Ji X, Capala J, Lipowska M, Nie S, Mao H, Yang L. Targeted Drug Delivery and Image-Guided Therapy of Heterogeneous Ovarian Cancer Using HER2-Targeted Theranostic Nanoparticles. Theranostics. 2019 Jan 24;9(3):778-795. doi: 10.7150/thno.29964. PMID: 30809308; PMCID: PMC6376473.
Jiaran Zhang, Huichun Tian, Lili Mao, Lu Si, Treatment of acral and mucosal melanoma: Current and emerging targeted therapies, Critical Reviews in Oncology/Hematology,Volume 193, 2024,104221,ISSN 1040-8428, https://doi.org/10.1016/j.critrevonc.2023.104221. (https://www.sciencedirect.com/science/article/pii/S1040842823003098)
Sandeep Wadekar, Dileep Kumar Singh, A modified convolutional neural network framework for categorizing lung cell histopathological image based on residual network, Healthcare Analytics, Volume 4, 2023, 100224, ISSN 2772-4425, https://doi.org/10.1016/j.health.2023.100224. (https://www.sciencedirect.com/science/article/pii/S2772442523000916)
Abid Haleem, Mohd Javaid, Ravi Pratap Singh, Shanay Rab, Rajiv Suman, Applications of nanotechnology in medical field: a brief review, Global Health Journal, Volume 7, Issue 2, 2023,Pages 70-77,ISSN 2414-6447, https://doi.org/10.1016/j.glohj.2023.02.008. (https://www.sciencedirect.com/science/article/pii/S2414644723000337)
Malik S, Muhammad K, Waheed Y. Nanotechnology: A Revolution in Modern Industry. Molecules. 2023 Jan 9;28(2):661. doi: 10.3390/molecules28020661. PMID: 36677717; PMCID: PMC9865684.
Yan Hu, Peishan Hu, Xiaozhong Peng, TIM-3 blockade: immune and targeted therapy in DIPG, Trends in Molecular Medicine, 2023, ISSN 1471-4914, https://doi.org/10.1016/j.molmed.2023.11.014. (https://www.sciencedirect.com/science/article/pii/S1471491423002769)
Elizabeth Silver, Alessia Argiro, Kimberly Hong, Eric Adler, Gene therapy vector-related myocarditis, International Journal of Cardiology, 2023, 131617,ISSN 0167-5273, https://doi.org/10.1016/j.ijcard.2023.131617. (https://www.sciencedirect.com/science/article/pii/S0167527323017072)
Charlotte O’Brien Gore, Amy Billman, Suchete Hunjan, Jayne Colebrook, Desmond Choy, Wilson Li, Jack Haynes, Jennifer Wade, Emily Hobern, Louisa McDonald, Sophie Papa, Martijn Brugman, Shahram Kordasti, Claudia Montiel-Equihua, Pre-treatment with systemic agents for advanced NSCLC elicits changes in the phenotype of autologous T cell therapy products,Molecular Therapy - Oncolytics,Volume 31, 2023,100749, ISSN 2372-7705, https://doi.org/10.1016/j.omto.2023.100749. (https://www.sciencedirect.com/science/article/pii/S2372770523000980)
Li, L., Yang, L., Yang, L. dkk. Farmakologi jaringan: cahaya penuntun yang terang dalam cara mengeksplorasi pengobatan tepat yang dipersonalisasi dari pengobatan tradisional Tiongkok. Dagu Med 18 , 146 (2023). https://doi.org/10.1186/s13020-023-00853-2
Xue H., Li J., Xie H., Wang Y. Review of drug repositioning approaches and resources. International Journal of Biological Sciences. 2018;14(10):1232–1244. doi: 10.7150/ijbs.24612.
Barabási A.L., Gulbahce N., Loscalzo J. Network medicine: A network-based approach to human disease. Nature Reviews Genetics. 2011;12(1):56–68. doi: 10.1038/nrg2918.
