Sintesis Dan Karakterisasi Hidrogel Berbasis Selulosa untuk Aplikasi Kesehatan
Keywords:
Hidrogel, Isolasi, Selulosa, KesehatanAbstract
Hidrogel selulosa telah menarik perhatian luas dalam bidang kesehatan karena sifatnya yang biokompatibel, biodegradable, dan memiliki kapasitas penyerapan air yang tinggi. Studi ini membahas sintesis hidrogel selulosa melalui berbagai metode, termasuk fermentasi bakteri, modifikasi kimia, dan kombinasi dengan polimer lain untuk meningkatkan sifat mekanik serta bioaktivitasnya. Aplikasi utama hidrogel selulosa meliputi pembalut luka, sistem penghantaran obat, dan rekayasa jaringan, di mana material ini berperan dalam mempercepat regenerasi sel dan meningkatkan efisiensi terapi. Meskipun memiliki keunggulan signifikan, tantangan seperti stabilitas jangka panjang dan kemampuan pelepasan obat yang terkontrol masih perlu disempurnakan. Dengan kemajuan teknologi material, hidrogel selulosa terus menunjukkan potensi besar dalam inovasi medis, menawarkan solusi yang lebih efektif dan ramah lingkungan dalam terapi kesehatan
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Chang, C., & Zhang, L. (2011). Cellulose-based hydrogels: Present status and application prospects. Carbohydrate Polymers, 84(1), 40-53. https://doi.org/10.1016/j.carbpol.2010.12.023
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Gorgieva, S., & Trček, J. (2019). Bacterial cellulose: Production, modification and perspectives in biomedical applications. Nanomaterials, 9(10), 1352. https://doi.org/10.3390/nano9101352
Jiang, G., Zhang, Q., & Jiang, L. (2019). Recent advances in cellulose-based hydrogels for biomedical applications. Carbohydrate Polymers, 224, 115119. https://doi.org/10.1016/j.carbpol.2019.115119
Jia, Y. T., Gong, J., & Gu, X. H. (2007). Fabrication and characterization of poly (vinyl alcohol)/chitosan blend nanofibers produced by electrospinning method. Carbohydrate Polymers, 67(3), 403-409. https://doi.org/10.1016/j.carbpol.2006.06.010
Keshk, S. M. (2014). Bacterial cellulose production and its industrial applications. Journal of Bioprocessing & Biotechniques, 4(2), 1-10. https://doi.org/10.4172/2155-9821.1000150
Klemm, D., Heublein, B., & Fink, H. P. (2005). Cellulose: Fascinating biopolymer and sustainable raw material. Angewandte Chemie International Edition, 44(22), 3358-3393. https://doi.org/10.1002/anie.200460587
Kumar, A., Han, S. S., & Purohit, S. D. (2020). Bacterial cellulose and its versatile applications in the field of wound healing and tissue engineering. Journal of Biomaterials Science, Polymer Edition, 31(6), 718-745. https://doi.org/10.1080/09205063.2020.1726763
Li, X., & Yang, X. (2021). Recent advances in cellulose-based hydrogels for biomedical applications. Progress in Polymer Science, 116, 101388. https://doi.org/10.1016/j.progpolymsci.2020.101388
Lin, W. C., Lien, C. C., & Yeh, H. J. (2013). Bacterial cellulose and bacterial cellulose–chitosan membranes for wound dressing applications. Carbohydrate Polymers, 94(1), 603-611. https://doi.org/10.1016/j.carbpol.2013.01.076
Liu, Y., Huang, W., & Zhang, T. (2020). Bacterial cellulose-based hydrogels for biomedical applications: A review. International Journal of Biological Macromolecules, 154, 1319-1331. https://doi.org/10.1016/j.ijbiomac.2019.11.104
Pereira, R. F., & Bartolo, P. J. (2016). Bacterial cellulose polymers: An overview of their use in developing wound dressings. Biotechnology and Bioengineering, 113(7), 1527-1536. https://doi.org/10.1002/bit.25986
Sharma, C., Bhardwaj, N. K., & Sharma, D. K. (2020). Cellulose-based hydrogels for biomedical applications. International Journal of Biological Macromolecules, 135, 849-860. https://doi.org/10.1016/j.ijbiomac.2019.05.153
Sun, B., Zhang, M., & Shen, J. (2018). Recent progress in functional modification of cellulose hydrogels. Journal of Materials Chemistry B, 6(44), 7174-7191. https://doi.org/10.1039/C8TB02125A
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Ullah, F., Othman, M. B. H., & Javed, F. (2015). Classification, processing and application of hydrogels: A review. Materials Science and Engineering: C, 57, 414-433. https://doi.org/10.1016/j.msec.2015.07.053
Wang, Z., Zhao, J., & Li, X. (2021). Modification strategies of cellulose-based hydrogels for biomedical applications. Materials Science & Engineering C, 121, 111820. https://doi.org/10.1016/j.msec.2020.111820
Zhang, H., & Wang, Z. (2019). Recent development of the biocompatibility and bioapplications of cellulose and its derivatives. Carbohydrate Research, 480, 12-21. https://doi.org/10.1016/j.carres.2019.05.001
Zhao, X., Li, J., & Wang, Y. (2022). Functional cellulose hydrogels: Synthesis, properties, and applications in biomedicine. Progress in Polymer Science, 125, 101482. https://doi.org/10.1016/j.progpolymsci.2021.101482
Zhang, Q., Wu, S., & Zhao, J. (2022). Recent advances in cellulose-based hydrogels for regenerative medicine. Advanced Healthcare Materials, 11(2), 2100984.
Zhao, X., Li, J., & Wang, Y. (2022). Functional cellulose hydrogels: Synthesis, properties, and applications in biomedicine. Progress in Polymer Science, 125, 101482
